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Scientific Resources

mTHPC-Loaded Extracellular Vesicles Significantly Improve mTHPC Diffusion and Photodynamic Activity in Preclinical Models

Journal and date : Pharmaceutics; 2020 Authors : Marie Millard, Solène Posty, Max Piffoux, Jordane Jasniewski,…

Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula

Journal and date : Nanoscale; 2021 Authors : Arthur Berger, Irami Araújo-Filho, Max Piffoux, Alba Nicolás-Boluda, Alice…

Development of extracellular vesicle-based medicinal products: Aposition paper of the group ‘‘Extracellular Vesicle translatiOn to clinicaLperspectiVEs – EVOLVE France”

Journal and date : Advanced Drug Delivery Reviews; 2021 Authors : Amanda K.A. Silva, Marie Morille, Max Piffoux,…

Engineering and loading therapeutic extracellular vesicles for clinicaltranslation: A data reporting frame for comparability

Journal and date : Advanced Drug Delivery Reviews; 2021 Authors : Max Piffoux, Jeanne Volatron, Kondareddy Cherukula,…

Technological advances towards extracellular vesicles mass production

Journal and date : Advanced Drug Delivery Reviews; 2021 Authors : Alice Grangier, Julien Branchu, Jeanne Volatron, Max…

Extracellular vesicles from adipose stromal cells combined with athermoresponsive hydrogel prevent esophageal stricture afterextensive endoscopic submucosal dissection in a porcine model

Journal and date : Nanoscale ; 2021 Authors : Elise Coffin, Alice Grangier, Guillaume Perrod, Max Piffoux, Iris…

mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors

Journal and date : Drug Delivery ; 2018 Authors : Marie Millard, Ilya Yakavets, Max Piffoux, Amanda Brun, Florence…

Immune Reprogramming Precision Photodynamic Therapy of Peritoneal Metastasis by Scalable Stem-Cell-Derived Extracellular Vesicles

Journal and date : ACS Nano ; 2021 Authors : Amandine Pinto, Iris Marangon, Julie Méreaux, Alba…

Thermoresponsive Gel Embedding Adipose Stem Cell-Derived Extracellular Vesicles Promotes Esophageal Fistula Healing in a Thermo-Actuated Delivery Strategy

Journal and date : ACS Nano ; 2018 Authors : Amanda K. A. Silva, Silvana Perretta, Guillaume Perrod, Laetitia Pidial,…

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

Journal and date : ACS Nano ; 2018 Authors : Max Piffoux, Amanda K. A. Silva, Claire Wilhelm, Florence Gazeau, David…

Extracellular vesicles for personalized medicine: The input of physically triggered production, loading and theranostic properties

Journal and date : Advanced Drug Delivery Reviews ; 2018 Authors : Max Piffoux, Alba Nicolás-Boluda, Vladmir…

The advantages of stem cell exosomes over stem cells

Extracellular vesicles (EVs) are subcellular entities produced by any cell type. They areproduced spontaneously or in…

Bead to bead transfer as scale-up method for mesenchymal stem cells expansion

Extracellular vesicles (EVs or exosome) are nano-sized subcellar particles involved in intercellular communication….

Extracellular lipid composition and their functions

To begin with a description of the roles of lipids either in extracellular vesicle (EV) formation or exosome…

Mass production of extracellular vesicles

The production of extracellular vesicles (EVs) is a major challenge in the coming years for the field of biotherapies….

EVs as diagnostic biomarkers of cancer

Despite numerous achievements and worldwide efforts to successfully cure cancer suffering patients, there is still a…

biogenesis of exosomes

Main takes on exosome biogenesis Regarding biogenesis of extracellular vesicles, three different pathways are…

Immunomodulatory properties of exosomes

Extracellular vesicles (EVs) offer a new approach for treatment of diseases and immunotherapy. EVs have already…

Exosome stability and storage

The stability of extracellular vesicles (EVs) both before injection and after injection is a critical parameter to…

Exosome immunogenicity

To allow its use in humans and avoid side effects/risks or loss of potency, extracellular vesicles have to be tested to…