Immunomodulatory properties of exosomes

Immunomodulatory properties of exosomes  Extracellular vesicles (EVs) offer a new approach for treatment of diseases and immunotherapy. EVs have already demonstrated their immunomodulatory properties: in the treatment of sepsis1, EVs…

Exosome stability and storage

The stability of extracellular vesicles (EVs) both before injection and after injection is a critical parameter to investigate. Once produced, extracellular vesicles have to be conserved correctly to ensure that…

Exosome immunogenicity

To allow its use in humans and avoid side effects/risks or loss of potency, extracellular vesicles have to be tested to know more about their immunogenicity. As an example, the…

Extracellular vesicle mechanism of action

A wide range of effects The field of extracellular vesicles has also to face regulator questions, in particular a tricky one: “what is the mechanism of action?” This question can…

Extracellular vesicles in health and disease

Extracellular vesicles in physiological conditions Extracellular vesicles are found in every body fluids, and play many important roles. In the blood, exosomes were first described as a way for the…

Exosomes at the age of uncertainty

Nowadays, everyday 5 to 10 papers are published in the EV field (1853 in 2017 only with the keyword “extracellular vesicles” in Pubmed), that mostly encompasses studies of the extracellular…

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