As the main mediators of intercellular communication, extracellular vesicles carry biomolecules such as proteins, lipids, and RNAs between cells and constitute a biological vector. In addition to these natural transfer properties, extracellular vesicles may be engineered to display exogenous properties. The possibility of customizing extracellular surface or cargo has opened up a wide range of perspectives for drug delivery. As a natural product, extracellular vesicles offer several advantages such as specifity (cellular recognition and internalization and able to deliver the cargo to specific distal cell), safety (low immune response) and stability . Extracellular vesicles as delivery systems have been already used to encapsulate siRNAs, miRNAs, drugs, radiotracers and inorganic nanoparticles in animal models [2,3,4].
 : EJ. Bunggulawa et al., Journal of nanobiotechnology, 2018, 16.
 : G. Kibria et al., Mol. Pharmaceutics, 2018, 15, 3625.
 : A. Aka Silva et al., Nanoscale, 2013, 5, 11374.
 : M. Piffoux et al., Adv. Drug. Deliv. Rev., 2018.