Main takes on exosome biogenesis Regarding biogenesis of extracellular vesicles, three different pathways are described in the literature corresponding to the three original subtypes. The exocytosis of exosomes follows an endosomal…
The stability of extracellular vesicles (EVs) both before injection and after injection is a critical parameter to investigate. Once produced, extracellular vesicles have to be conserved correctly to ensure that…
To allow its use in humans and avoid side effects/risks or loss of potency, extracellular vesicles have to be tested to know more about their immunogenicity. As an example, the…
A wide range of effects The field of extracellular vesicles has also to face regulator questions, in particular a tricky one: “what is the mechanism of action?” This question can…
Extracellular vesicles in physiological conditions Extracellular vesicles are found in every body fluids, and play many important roles. In the blood, exosomes were first described as a way for the…
Nowadays, everyday 5 to 10 papers are published in the EV field (1853 in 2017 only with the keyword “extracellular vesicles” in Pubmed), that mostly encompasses studies of the extracellular…