Exosome stability and storage
The stability of extracellular vesicles (EVs) both before injection and after injection is a critical parameter to investigate. Once produced, extracellular vesicles have to be conserved correctly to ensure that…
Exosome immunogenicity
To allow its use in humans and avoid side effects/risks or loss of potency, extracellular vesicles have to be tested to know more about their immunogenicity. As an example, the…
Extracellular vesicle mechanism of action
A wide range of effects The field of extracellular vesicles has also to face regulator questions, in particular a tricky one: “what is the mechanism of action?” This question can…
Extracellular vesicles in health and disease
Extracellular vesicles in physiological conditions Extracellular vesicles are found in every body fluids, and play many important roles. In the blood, exosomes were first described as a way for the…
Exosomes at the age of uncertainty
Nowadays, everyday 5 to 10 papers are published in the EV field (1853 in 2017 only with the keyword “extracellular vesicles” in Pubmed), that mostly encompasses studies of the extracellular…
Selection of the optimal cell source for extracellular vesicles production in regenerative medicine or drug delivery
Extracellular vesicles (EVs) are vesicles secreted by cells from several biogenesis pathways. Extracellular vesicles are currently developed for therapies mainly in regenerative medicine to replace stem cell therapy1,2, and in…